ChronoShield

ChronoShield

INGREDIENTS

BENEFITS

CHRONOSHIELD STUDIES

FAQS

Your cells have a built-in defense system that keeps them healthy and strong. But as you age, this system gets weaker and your cells become more vulnerable to damage and disease. This can affect your energy, vitality, and well-being. [1]

What if there was a way to boost your cell defense system and protect your cells from aging?

Nature has given us the answer: carotenoids, natural pigments that give plants their vibrant colors. They also help plants survive in harsh environments by absorbing harmful light and free radicals.

Some plants have developed even more powerful carotenoids and ways to enhance their effects. ChronoShield is based on these amazing plant protectors and has been carefully designed to deliver the best results for your health and longevity.

Ingredients

Chronoshield is more than just a supplement. It’s a powerful blend of nature’s best defenders that work together to shield your cells from aging and damage. 

Each ingredient is carefully selected from the highest quality source and backed by science to deliver optimal results for your health and longevity. 

Here’s what makes ChronoShield so unique and effective:

Lycopene

This red pigment is a potent antioxidant that protects your heart, skin, eyes, from oxidative stress and inflammation. It also helps you look younger and more radiant by boosting your skin’s natural collagen production and preventing UV damage. [2]

  • Antioxidant protection: Lycopene is a powerful antioxidant that can help protect against free radical damage and oxidative stress (1).
  • Heart health: Lycopene has been shown to help reduce inflammation and oxidative stress in the body, which can help support cardiovascular health (2).
  • Prostate health: Lycopene may help reduce the risk of prostate cancer and improve prostate health (3).
  • Skin health: Lycopene may help protect against UV damage and improve skin health (4).
  • Eye health: Lycopene may help protect against age-related macular degeneration and other eye diseases (5).
  • Anti-inflammatory effects: Lycopene has anti-inflammatory properties that may help reduce inflammation in the body (6).
  • Bone health: Lycopene may help improve bone health and reduce the risk of osteoporosis (7).
  1. Imran M, Ghorat F, Ul-Haq I, Ur-Rehman H, Aslam F, Heydari M, Shariati MA, Okuskhanova E, Yessimbekov Z, Thiruvengadam M, Hashempur MH, Rebezov M. Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders. Antioxidants. 2020; 9(8):706.
  2. Mozos, I., Stoian, D., Caraba, A., Malainer, C., Horbańczuk, J. O., & Atanasov, A. G. (2018). Lycopene and vascular health. Frontiers in pharmacology, 521.
  3. Wertz, K., Siler, U., & Goralczyk, R. (2004). Lycopene: modes of action to promote prostate health. Archives of biochemistry and biophysics, 430(1), 127-134.
  4. Grether‐Beck, S., Marini, A., Jaenicke, T., Stahl, W., & Krutmann, J. (2017). Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double‐blinded, placebo‐controlled, crossover study. British Journal of Dermatology, 176(5), 1231-1240.
  5. Shao, A., & Hathcock, J. N. (2006). Risk assessment for the carotenoids lutein and lycopene. Regulatory Toxicology and Pharmacology, 45(3), 289-298.
  6. Khan, U. M., Sevindik, M., Zarrabi, A., Nami, M., Ozdemir, B., Kaplan, D. N., … & Sharifi-Rad, J. (2021). Lycopene: Food sources, biological activities, and human health benefits. Oxidative Medicine and Cellular Longevity, 2021.
  7. Rao LG and Rao AV. Phytochemicals: Isolation, Characterisation and Role in Human Health:

Chapter 10: Oxidative Stress and Antioxidants in the Risk of Osteoporosis – Role of Phytochemical Antioxidants Lycopene and Polyphenol-containing Nutritional Supplements. Intech 2015.

Astaxanthin

This red-orange pigment is sourced from microalgae that thrive in harsh environments. It’s one of the strongest antioxidants in nature, with 6000 times more power than vitamin C. It helps you improve your endurance, skin, joints, eyes, brain, and heart health by fighting free radicals and inflammation. [3]

  • Antioxidant protection: Astaxanthin is a potent antioxidant that can help protect your cells from oxidative stress and free radical damage (1).
  • Skin health: Astaxanthin has been shown to improve skin elasticity, reduce fine lines and wrinkles, and protect against UV damage (2).
  • Joint health: Astaxanthin has anti-inflammatory properties that can help reduce joint pain and stiffness (3).
  • Cardiovascular health: Astaxanthin may help reduce inflammation and oxidative stress in the body, which can help support cardiovascular health (4).
  • Immune function: Astaxanthin may help boost immune function by reducing inflammation and supporting the production of antibodies (5).
  • Eye health: Astaxanthin may help protect against age-related macular degeneration and other eye diseases (6).
  • Brain health: Astaxanthin has been shown to have neuroprotective properties and may help improve cognitive function (7).
  • Exercise performance: Astaxanthin may help improve endurance and reduce muscle damage and soreness after exercise (8).
  1. Naguib, Y. M. (2000). Antioxidant activities of astaxanthin and related carotenoids. Journal of agricultural and food chemistry, 48(4), 1150-1154.
  2. Zhou, X., Cao, Q., Orfila, C., Zhao, J., & Zhang, L. (2021). Systematic review and meta-analysis on the effects of astaxanthin on human skin ageing. Nutrients, 13(9), 2917.
  3. Peng, Y. J., Lu, J. W., Liu, F. C., Lee, C. H., Lee, H. S., Ho, Y. J., … & Wang, C. C. (2020). Astaxanthin attenuates joint inflammation induced by monosodium urate crystals. The FASEB Journal, 34(8), 11215-11226.
  4. Peng, Y. J., Lu, J. W., Liu, F. C., Lee, C. H., Lee, H. S., Ho, Y. J., … & Wang, C. C. (2020). Astaxanthin attenuates joint inflammation induced by monosodium urate crystals. The FASEB Journal, 34(8), 11215-11226.
  5. Park, J. S., Chyun, J. H., Kim, Y. K., Line, L. L., & Chew, B. P. (2010). Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutrition & metabolism, 7, 1-10.
  6. Giannaccare, G., Pellegrini, M., Senni, C., Bernabei, F., Scorcia, V., & Cicero, A. F. G. (2020). Clinical applications of astaxanthin in the treatment of ocular diseases: Emerging insights. Marine drugs, 18(5), 239.
  7. Wu, H., Niu, H., Shao, A., Wu, C., Dixon, B. J., Zhang, J., … & Wang, Y. (2015). Astaxanthin as a potential neuroprotective agent for neurological diseases. Marine drugs, 13(9), 5750-5766.
  8. Brown, D. R., Gough, L. A., Deb, S. K., Sparks, S. A., & McNaughton, L. R. (2018). Astaxanthin in exercise metabolism, performance and recovery: a review. Frontiers in nutrition, 4, 76.

LUTEIN

This yellow-green pigment is derived from leafy greens that are rich in nutrients. It’s an essential carotenoid that supports your eye health, vision, skin health, cognitive function, and cardiovascular health by shielding your eyes from harmful blue light and reducing inflammation. [4]

  • Eye health: Lutein is a carotenoid that is important for eye health. It can help protect against age-related macular degeneration, cataracts, and other eye diseases (1).
  • Skin health: Lutein may help protect against UV damage and improve skin hydration and elasticity (2)
  • Cognitive function: Lutein may help improve cognitive function and memory, particularly in older adults (3).
  • Cardiovascular health: Lutein has been shown to have anti-inflammatory properties that may help reduce the risk of cardiovascular disease (4).
  • Immune function: Lutein may help support immune function by reducing inflammation and oxidative stress in the body (5).
  1. Ma, L., & Lin, X. M. (2010). Effects of lutein and zeaxanthin on aspects of eye health. Journal of the Science of Food and Agriculture, 90(1), 2-12.
  2. Palombo, P., Fabrizi, G., Ruocco, V., Ruocco, E., Fluhr, J., Roberts, R., & Morganti, P. (2007). Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled study. Skin pharmacology and physiology, 20(4), 199-210.
  3. Johnson, E. J. (2012). A possible role for lutein and zeaxanthin in cognitive function in the elderly. The American journal of clinical nutrition, 96(5), 1161S-1165S.
  4. Chung, R. W., Leanderson, P., Lundberg, A. K., & Jonasson, L. (2017). Lutein exerts anti-inflammatory effects in patients with coronary artery disease. Atherosclerosis, 262, 87-93.
  5. Lee, E. H., Faulhaber, D., Hanson, K. M., Ding, W., Peters, S., Kodali, S., & Granstein, R. D. (2004). Dietary lutein reduces ultraviolet radiation-induced inflammation and immunosuppression. Journal of Investigative Dermatology, 122(2), 510-517.

Zeaxanthin

This yellow-orange pigment is found in vibrant fruits and vegetables that are full of antioxidants. It works with lutein to protect your eyes from age-related diseases, improve your skin health, cognitive function, cardiovascular health, and immune function by reducing inflammation and oxidative stress. [5]

  • Eye health: Zeaxanthin is a carotenoid that is important for eye health. It can help protect against age-related macular degeneration, cataracts, and other eye diseases (1).
  • Skin health: Zeaxanthin may help protect against UV damage and improve skin hydration and elasticity (2).
  • Cognitive function: Zeaxanthin may help improve cognitive function and memory, particularly in older adults (3).
  • Cardiovascular health: Zeaxanthin has been shown to have anti-inflammatory properties that may help reduce the risk of cardiovascular disease (4).
  • Anti-inflammatory effects: Zeaxanthin has anti-inflammatory properties that may help reduce inflammation in the body (5).
  • Immune function: Zeaxanthin may help support immune function by reducing inflammation and oxidative stress in the body.
  1. Scripsema, N. K., Hu, D. N., & Rosen, R. B. (2015). Lutein, zeaxanthin, and meso-zeaxanthin in the clinical management of eye disease. Journal of ophthalmology, 2015.
  2. Roberts, R. L. (2013). Lutein, zeaxanthin, and skin health. American Journal of Lifestyle Medicine, 7(3), 182-185.
  3. Johnson, E. J. (2014). Role of lutein and zeaxanthin in visual and cognitive function throughout the lifespan. Nutrition reviews, 72(9), 605-612.
  4. Rizos, E. C., & Ntzani, E. E. (2014). ω-3 fatty acids and lutein+ Zeaxanthin supplementation for the prevention of cardiovascular disease. JAMA internal medicine, 174(5), 771-772.
  5. Firdous, A. P., Kuttan, G., & Kuttan, R. (2015). Anti-inflammatory potential of carotenoid meso-zeaxanthin and its mode of action. Pharmaceutical biology, 53(7), 961-967.

vitamin e

This natural antioxidant helps protect your cells from damage, support your immune function, and promote your skin, hair, nail, eye, brain, fertility, and menopause health. [6]

  • Antioxidant protection: Vitamin E is a powerful antioxidant that can help protect against free radical damage and oxidative stress (1).
  • Heart health: Vitamin E may help reduce the risk of cardiovascular disease by reducing inflammation and oxidative stress in the body (2).
  • Skin health: Vitamin E may help improve skin hydration and elasticity, and can help protect against UV damage (3).
  • Immune function: Vitamin E may help support immune function by reducing inflammation and oxidative stress in the body (4, 5).
  • Eye health: Vitamin E may help protect against age-related macular degeneration and other eye diseases (6).
  • Neuroprotection: Vitamin E may have neuroprotective properties and may help reduce the risk of cognitive decline and dementia (7).
  • Fertility: Vitamin E may help improve fertility in both men and women (8).
  • Menopause: Vitamin E may help reduce hot flashes and other symptoms of menopause (9, 10).
  1. Niki, E., & Noguchi, N. (2004). Dynamics of antioxidant action of vitamin E. Accounts of chemical research, 37(1), 45-51.
  2. G. Shekelle, P., Morton, S. C., Jungvig, L. K., Udani, J., Spar, M., Tu, W., … & Hardy, M. (2004). Effect of supplemental vitamin E for the prevention and treatment of cardiovascular 
  3. disease. Journal of general internal medicine, 19(4), 380-389.
  4. Packer, L., & Valacchi, G. (2002). Antioxidants and the response of skin to oxidative stress: vitamin E as a key indicator. Skin Pharmacology and Physiology, 15(5), 282-290.
  5. Wu, D., & Meydani, S. N. (2019). Vitamin E, immune function, and protection against infection. Vitamin E in human health, 371-384.
  6. Lewis, E. D., Meydani, S. N., & Wu, D. (2019). Regulatory role of vitamin E in the immune system and inflammation. IUBMB life, 71(4), 487-494.
  7. Chew, E. Y., & Clemons, T. (2005). Vitamin E and the age-related eye disease study supplementation for age-related macular degeneration. Archives of Ophthalmology, 123(3), 395-396.
  8. Khanna, S., Roy, S., Slivka, A., Craft, T. K., Chaki, S., Rink, C., … & Sen, C. K. (2005). Neuroprotective properties of the natural vitamin E α-tocotrienol. Stroke, 36(10), e144-e152.
  9. Kessopoulou, E., Powers, H. J., Sharma, K. K., Pearson, M. J., Russell, J. M., Cooke, I. D., & Barratt, C. L. (1995). A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility. Fertility and sterility, 64(4), 825-831.
  10. Ziaei, S., Kazemnejad, A., & Zareai, M. (2007). The effect of vitamin E on hot flashes in menopausal women. Gynecologic and obstetric investigation, 64(4), 204-207.
  11. Golmakani, N., Parnan Emamverdikhan, A., Zarifian, A., Sajadi Tabassi, S. A., & Hassanzadeh, M. (2019). Vitamin E as alternative local treatment in genitourinary syndrome of menopause: a randomized controlled trial. International Urogynecology Journal, 30, 831-837.

Effects & Benefits 

By taking ChronoShield every day, you’ll enjoy a range of benefits that will make you feel younger, stronger, and healthier.

Here’s what ChronoShield can do for you:

Cellular Protection:

Your cells are constantly under attack from free radicals that cause oxidative stress, which can lead to aging and disease. ChronoShield’s powerful carotenoids act as natural shields that neutralize these free radicals and protect your cells from damage. This helps you maintain healthy and youthful cells that function optimally. [7]

Sun Protection:

Your skin is constantly exposed to harmful ultraviolet (UV) radiation from the sun, which can lead to skin damage, premature aging, and an increased risk of skin cancer. ChronoShield harnesses the power of nature’s own sun protectors to shield your skin from these harmful effects.  Lycopene has been shown to possess strong antioxidant properties that help protect against UV-induced skin damage and reduce the risk of sunburn. [16]

Anti-Inflammatory Support:

Chronic inflammation is a silent killer that can trigger many health problems, from joint pain to heart disease. ChronoShield helps prevent inflammaging, which is the chronic inflammation caused by aging. By reducing inflammation in your body, ChronoShield helps you avoid many age-related diseases and improve your quality of life. [8]

Increased Energy and Vitality:

Your energy levels and vitality depend on how well your cells are functioning. By combating oxidative stress and supporting overall cellular health, ChronoShield helps increase your energy levels and overall vitality. This helps you feel more alert, active, and enthusiastic about life. [13]

Enhanced Immune Function:

Your immune system is your body’s defense against infections and diseases. But as you age, your immune system weakens and becomes less effective. ChronoShield helps strengthen your immune system with the proven benefits of carotenoids, which help boost your immune response and fight off pathogens. [9]

Antioxidant Defense:

Antioxidants are substances that help protect your body from the damaging effects of free radicals and oxidative stress. ChronoShield is rich in potent antioxidants that work synergistically to provide you with a comprehensive antioxidant defense. This helps you fight off diseases, slow down aging, and live longer. [3]

Improved Eye Health:

Your eyes are one of the most important organs in your body, but they are also one of the most vulnerable to aging and damage. ChronoShield’s combination of lutein and zeaxanthin supports optimal eye health by protecting your eyes from age-related macular degeneration and harmful blue light exposure. These carotenoids also help improve your vision, contrast sensitivity, and glare tolerance. [5]

Supports Healthy Aging:

Aging is inevitable, but it doesn’t have to be unpleasant. With its unique blend of potent carotenoids and antioxidants, ChronoShield slows down the aging process at the cellular level, allowing you to age gracefully and maintain a higher quality of life. ChronoShield helps you look younger, feel better, and live longer. [14]

Boosted Cognitive Function:

Your brain is the control center of your body, but it also suffers from aging and oxidative stress. ChronoShield supports optimal brain health by promoting blood flow, oxygen delivery, and nutrient uptake to your brain cells. This helps reduce inflammation and protect your brain from cognitive decline and memory loss. [10]

Menopause Effect:

If you are going through menopause, you may be looking for natural ways to ease your symptoms. One nutrient that may help you is vitamin E. Vitamin E is a powerful antioxidant that protects your cells from damage and supports your immune system. It also has some benefits for menopause symptoms, such as hot flashes and vaginal dryness. [15]

Skin Health and Radiance:

Your skin is the largest organ in your body, but it also shows the signs of aging the most. ChronoShield’s antioxidant properties enhance your skin’s natural radiance and elasticity by stimulating collagen production and preventing UV damage. This helps reduce the appearance of fine lines, wrinkles, sagging, and age spots. [11]

Cardiovascular Support:

Your heart is the most vital organ in your body, but it also faces many challenges as you age. ChronoShield’s ingredients, such as lycopene, contribute to heart health by reducing oxidative stress and inflammation in your blood vessels. This helps lower your blood pressure, cholesterol, and triglycerides levels, and prevent plaque buildup and blood clots. [12]

  1. Yousefzadeh M, Henpita C, Vyas R, Soto-Palma C, Robbins P, Niedernhofer L. DNA damage-how and why we age? Elife. 2021 Jan 29;10:e62852. doi: 10.7554/eLife.62852. PMID: 33512317; PMCID: PMC7846274.
  2. Bin-Jumah MN, Nadeem MS, Gilani SJ, Mubeen B, Ullah I, Alzarea SI, Ghoneim MM, Alshehri S, Al-Abbasi FA, Kazmi I. Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases. Antioxidants (Basel). 2022 Jan 26;11(2):232. doi: 10.3390/antiox11020232. PMID: 35204115; PMCID: PMC8868303.
  3. Bjørklund G, Gasmi A, Lenchyk L, Shanaida M, Zafar S, Mujawdiya PK, Lysiuk R, Antonyak H, Noor S, Akram M, Smetanina K, Piscopo S, Upyr T, Peana M. The Role of Astaxanthin as a Nutraceutical in Health and Age-Related Conditions. Molecules. 2022 Oct 23;27(21):7167. doi: 10.3390/molecules27217167. PMID: 36363994; PMCID: PMC9655540.
  4. Kijlstra A, Tian Y, Kelly ER, Berendschot TT. Lutein: more than just a filter for blue light. Prog Retin Eye Res. 2012 Jul;31(4):303-15. doi: 10.1016/j.preteyeres.2012.03.002. Epub 2012 Mar 21. PMID: 22465791.
  5. Mrowicka M, Mrowicki J, Kucharska E, Majsterek I. Lutein and Zeaxanthin and Their Roles in Age-Related Macular Degeneration-Neurodegenerative Disease. Nutrients. 2022 Feb 16;14(4):827. doi: 10.3390/nu14040827. PMID: 35215476; PMCID: PMC8874683.
  6. Keen MA, Hassan I. Vitamin E in dermatology. Indian Dermatol Online J. 2016 Jul-Aug;7(4):311-5. doi: 10.4103/2229-5178.185494. PMID: 27559512; PMCID: PMC4976416.
  7. Ozhogina OA, Kasaikina OT. Beta-carotene as an interceptor of free radicals. Free Radic Biol Med. 1995 Nov;19(5):575-81. doi: 10.1016/0891-5849(95)00064-5. PMID: 8529916.
  8. Kawata A, Murakami Y, Suzuki S, Fujisawa S. Anti-inflammatory Activity of β-Carotene, Lycopene and Tri-n-butylborane, a Scavenger of Reactive Oxygen Species. In Vivo. 2018 Mar-Apr;32(2):255-264. doi: 10.21873/invivo.11232. PMID: 29475907; PMCID: PMC5905192.
  9. Huang Z, Liu Y, Qi G, Brand D, Zheng SG. Role of Vitamin A in the Immune System. J Clin Med. 2018 Sep 6;7(9):258. doi: 10.3390/jcm7090258. PMID: 30200565; PMCID: PMC6162863.
  10. Tanprasertsuk J, Scott TM, Barbey AK, Barger K, Wang XD, Johnson MA, Poon LW, Vishwanathan R, Matthan NR, Lichtenstein AH, Ferland G, Johnson EJ. Carotenoid-Rich Brain Nutrient Pattern Is Positively Correlated With Higher Cognition and Lower Depression in the Oldest Old With No Dementia. Front Nutr. 2021 Jun 29;8:704691. doi: 10.3389/fnut.2021.704691. PMID: 34268331; PMCID: PMC8275828.
  11. Stahl W, Sies H. Carotenoids and protection against solar UV radiation. Skin Pharmacol Appl Skin Physiol. 2002 Sep-Oct;15(5):291-6. doi: 10.1159/000064532. PMID: 12239422.
  12. Gammone MA, Riccioni G, D’Orazio N. Carotenoids: potential allies of cardiovascular health? Food Nutr Res. 2015 Feb 6;59:26762. doi: 10.3402/fnr.v59.26762. PMID: 25660385; PMCID: PMC4321000.
  13. Brown DR, Gough LA, Deb SK, Sparks SA, McNaughton LR. Astaxanthin in Exercise Metabolism, Performance and Recovery: A Review. Front Nutr. 2018 Jan 18;4:76. doi: 10.3389/fnut.2017.00076. PMID: 29404334; PMCID: PMC5778137.
  14. Tan BL, Norhaizan ME. Carotenoids: How Effective Are They to Prevent Age-Related Diseases? Molecules. 2019 May 9;24(9):1801. doi: 10.3390/molecules24091801. PMID: 31075966; PMCID: PMC6539799.
  15. Feduniw S, Korczyńska L, Górski K, Zgliczyńska M, Bączkowska M, Byrczak M, Kociuba J, Ali M, Ciebiera M. The Effect of Vitamin E Supplementation in Postmenopausal Women-A Systematic Review. Nutrients. 2022 Dec 29;15(1):160. doi: 10.3390/nu15010160. PMID: 36615817; PMCID: PMC9824658.
  16. Kumaran S, et al. Protective effect of lycopene on ultraviolet B-induced skin photoaging in Swiss albino mice. J Cosmet Dermatol. 2019 Apr;18(2):541-549. doi: 10.1111/jocd.12560. PubMed PMID: 30675967.

ChronoShield: On-going Studies

Study on Protection Against Oxidative Damage (in the case of radiation) with Ruđer Bošković Institute, Zagreb

In cooperation with the renowned IRB research institute in Zagreb, Chronoshield is going to be tested for its ability to protect against the extreme oxidative damage of radiation. The goal of this study is to demonstrate that even under the highest level of stress, the shielding power of Chronoshield can guarantee cellular and organism protection.

Results: We will keep you updated on the results of this study!

Analysis of the Influence of ChronoShield Food Supplement on The Mobility of the Musculoskeletal System with clinic ANALIZA, Croatia

Chronoshield is currently under clinical evaluation for its effect on joint pain and inflammaging. In this study, a cohort of volunteers are being monitored during several months for several markers of inflammation and oxidative stress as well as their self-reported joint pain level. This study is being held in cooperation between Zagreb Hospital and Clinic ANALIZA in Split and Zagreb.

Results: We will keep you updated on the results of this study!

ChronoShield combines powerful carotenoids that work together to fight harmful free radicals and inflammation in your body. This slows down aging at the cellular level.

By taking ChronoShield™ daily, you can boost your cellular health, immune function, and longevity.

ChronoShield has a blend of potent carotenoids, including lycopene, astaxanthin, lutein, zeaxanthin, and alpha-tocopherol. These ingredients protect your cells and support your overall health and well-being.

ChronoShield™ protects your cells directly and has other benefits:

  • It boosts your protection from aging up to 4 times more than the main antioxidants like alpha tocopherol.
  • It absorbs light and protects you from UV damage.

If you have any questions about ChronoShield™ that are not answered here, or are not in our FAQS page, please contact us here through our contact form.  We are happy to help you with any inquiries or feedback.

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